To make your layout responsive, you need to make layout & style overrides for each respective viewport (the visible area of your Shopify page for the user based on their device).
You can create the overrides by toggling between the different viewports at the top of the builder while designing your pages.
We recommend starting with the desktop version and working your way down to the laptop version, then proceeding to the tablet viewport, and lastly, finalizing your layout design on mobile.